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Carl-Philipp Heisenberg 院士

单位:Institute of Science and Technology Austria (ISTA)


Carl-Philips Heisenberg,发育与细胞生物学家,奥地利科技与科学研究所(Institute of Science and Technology Austria, Austria)教授,德国国家科学院院士、欧洲分子生物学组织(EMBO)院士。他的主要研究兴趣在于组织和器官形成的机制,特别关注于胚胎形成过程中的细胞黏附、极性、运动、分裂等过程;特别是利用斑马鱼和海鞘模型,研究发育中机械力的生成、传导、接受和感知等过程。Heisenberg教授的创新工作为他赢得了诸如2019年德国科学院的卡鲁斯奖(Carus Medal)等诸多荣誉。他的主要代表论文包括Cell(2021, 2019X3, 2015)、Science(2012X2)、Nature Cell Biology(2019,2017,2008)等,他还担任Science、Developmetal Cell、EMBO Journal、Current Biology等众多国际学术刊物的科学编辑或科学顾问委员。

主要代表性论文:

1. *Petridou NI, Corominas-Murtra B, Heisenberg CP*, Hannezo E (*co-corresponding and lead author) Rigidity percolation uncovers the structural basis of embryonic tissue phase transitions.Cell. 2021 Apr 1;184(7):1914-1928.e19. doi: 10.1016/j.cell.2021.02.017.

2. *Schwayer C, Shamipour S, Pranjic-Ferscha K, Schauer A, Balda M, Tada M, Matter K, Heisenberg CP. Mechanosensation of tight junctions by ZO-1 phase separation and flow.Cell. 2019 Oct 31;179(4):937-952. DOI: 10.1016/j.cell.2019.10.006

3. Shamipour S, Kardos R, Xue SL, Hof B, Hannezo E, Heisenberg CP. Bulk Actin Dynamics Drives Phase Segregation in Zebrafish Oocytes.Cell. 2019 May 30;177(6):1463-1479. DOI: 10.1016/j.cell.2019.04.030

4. Xia P, Gütl D, Zheden V, Heisenberg CP. Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity.Cell. 2019 Mar 7;176(6):1379-1392. DOI: 10.1016/j.cell.2019.01.019

5. *Petridou NI, Grigolon S, Salbreux G, Hannezo E, Heisenberg CP. Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling.Nat Cell Biol.2019 Feb;21(2):169-178. DOI: 10.1038/s41556-018-0247-4

6. Smutny M, Ákos Z, Grigolon S, Shamipour S, Ruprecht V, Čapek D, Behrndt M, Papusheva E, Tada M, Hof B, Vicsek T, Salbreux G, Heisenberg CP. Friction forces position the neural anlage.Nat Cell Biol. 2017 Apr;19(4):306-317. DOI: 10.1038/ncb3492

7. Ruprecht V, Wieser S, Callan-Jones A, Smutny M, Morita H, Sako K, Barone V, RitschMarte M, Sixt M, Voituriez R, Heisenberg CP. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.Cell.2015 Feb 12;160(4):673-85. DOI: 10.1016/j.cell.2015.01.008

8. Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill SW, Heisenberg CP. Forces driving epithelial spreading in zebrafish gastrulation.Science. 2012 Oct 12;338(6104):257-60. DOI: 10.1126/science.1224143

9. Maître JL, Berthoumieux H, Krens SF, Salbreux G, Jülicher F, Paluch E, Heisenberg CP. Adhesion functions in cell sorting by Mechanically Coupling the Cortices of Adhering Cells.Science. 2012 Oct 12;338(6104):253-6. DOI: 10.1126/science.1225399

10. Krieg M, Arboleda Y, Puech PH, Käfer J, Graner F, Muller DJ and Heisenberg CP. Tensile forces govern germ layer organization during gastrulation.Nat Cell Biol.2008 Apr;10(4):429-36. DOI: 10.1038/ncb1705